**Purpose:** Primary mediastinal large B-cell lymphoma (PMBCL) is a rare aggressive lymphoma predominantly affecting young female patients. Large-scale genomic investigations and genetic markers for risk stratification are lacking. **Patients and …
Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier *ZNF217* in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of *ZNF217* alterations remain unknown, we …